One of the country's oldest instruments, the begena was once reserved for the elite -- and effectively banned during the Marxist Derg government between 1974 and 1991.
But it is experiencing a resurgence among Ethiopia's artistic community.
Ermias Haylay, 23, started playing as a teenager and founded a school to train students.
He now performs regularly in retirement homes and hospitals to bring "a bit of joy" after seeing its therapeutic effects.
Biruktawit is one of his students who often plays with the group at a nursing home in Addis Ababa.
The begena "is medicine for the soul", said Biruktawit, 23, who has been playing the instrument for about a year.
Legend has it that the instrument was brought over from Israel in the 10th century BC by Menelik I, Ethiopia's first emperor, who received it from King David.
For centuries, the instrument's music has accompanied the prayers and meditations of monks of the Ethiopian Orthodox Tewahedo Church, which represents about 40 percent of Ethiopia's 120 million people.
That association with religion meant it fell from favour as the country turned towards communism, but it has slowly returned.
Resembling a harp or a large lyre, trapezium-shaped and about a metre tall, it has 10 strings -- traditionally made from sheep's intestines -- that symbolise the Ten Commandments.
It is plucked with the left hand, either bare or with a plectrum, while players wear a netela -- a traditional white cloth -- draped across the chest for men, and in the form of a veil for women.
- Begena therapy -
At Grace Nursing Home for the elderly, the begena brings healing.
Sitting in a small courtyard where residents gather to listen to the soothing melodies, 60-year-old Solomon Daniel Yohanes gently shakes his head in his wheelchair as the tunes fill the air.
Yohanes has been a resident for two years and said the begena has "brought him peace".
"When you're looking for God, you look for him in different ways, and I see the begena as God speaking in his own voice," he said.
Natnael Hailu, a doctor and co-founder of the institution, admits to being "shocked" to see his patients "forget their pain and drift into sleep" to the tune of the instrument.
"It calms their heart rate, lowers their blood pressure and soothes them. More than any other instrument, begena therapy has a real calming effect," he said.
Gene Bukhman, a cardiologist and lecturer at Harvard University who attended one of the performances, told AFP the begena's melodies could have a positive influence on people suffering from chronic illnesses.
- Positive influence -
Ermias, who founded the Eman Begena School, started playing when he was 15 but admits he was not immediately convinced.
"I found it smelled bad since some parts come from sheep," he said.
But he soon came to love its "spiritual aspect".
His trips to nursing homes and hospitals has even led to him playing during surgeries.
Before long, he noticed "extraordinary changes" in patients with Alzheimer's, dementia and autism.
"They became very calm," he said.
Demands for the lessons have been booming and he hopes to open schools around the world to help more patients.
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© Agence France-Presse